1. Zhiyong Ding, PhD - Rivkin Center
Missing: Zhicheng | Show results with:Zhicheng
Zhiyong Ding, PhDThe University of Texas MD Anderson Cancer Center Identification of novel interaction partners of p110 and p85 in ovarian cancer cells Ovarian cancer, like all cancer, is a disease of gene malfunctions. This study will look at a gene known to control cancer cells (PIK3CA) and the proteins it interacts with. These proteins […]
2. Zhicheng Zhou - MD Anderson Cancer Center
Fingerprint. Dive into the research topics where Zhicheng Zhou is active. These topic labels come from the works of this person. Together they form a unique ...
Dive into the research topics where Zhicheng Zhou is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
3. [PDF] Zhicheng Ji: Curriculum Vitae - Biostatistics
... Ding Ding, Zhicheng Ji, Mark T. Bedford, Antonella Galli, Hongkai Ji and ... cancer: development of a prognostic model through a crowdsourced challenge ...
4. Quantitative evidence for early metastatic seeding in colorectal ...
This conceptual and analytical framework provides quantitative in vivo evidence that systemic spread can occur early in colorectal cancer.
Analysis of genomic data within a spatial tumor growth model and statistical inference framework indicates that early disseminated cells commonly seed metastases while the carcinoma is clinically undetectable.
5. Most metastatic colorectal cancers have spread before diagnosis
Jun 17, 2019 · Up to 80% of metastatic colorectal cancers are likely to have spread to distant locations in the body before the original tumor has exceeded the size of a ...
Colorectal cancers often spread before the initial tumor is detected, according to a new Stanford study. Identifying patients in whom early metastasis is likely could better guide treatment decisions.
6. Li Ning | Breast Oncology - Sun Yat-sen University Cancer Center
He engaged in surgery-based multidisciplinary treatment and medical case management of breast cancer, including surgical treatment, chemotherapy, endocrine ...
sun yat-sen university cancer center,Sun Yat-sen University Cancer Center,SYSUCC
7. Pan-cancer organoid validation of tumor outlier chromosomal ...
Oct 6, 2021 · Hart, Jie Ding, Zhicheng Ma, View ORCID ProfileSammy Barkal, View ... This article is a preprint and has not been certified by peer review [what ...
Somatic copy number gains are pervasive in many cancer types, yet their roles in oncogenesis are often poorly explored. This lack of understanding is in part due to broad extensions of copy gains across cancer genomes spanning large chromosomal regions, obscuring causal driver loci. Here we employed a multi-tissue pan-organoid modeling approach to validate candidate oncogenic loci identified within pan-cancer TCGA data by the overlap of extreme copy number amplifications with extreme expression dysregulation for each gene. The candidate outlier loci nominated by this integrative computational analysis were functionally validated by infecting cancer type-specific barcoded full length cDNA lentiviral libraries into cognate minimally transformed human and mouse organoids bearing initial oncogenic mutations from esophagus, oral cavity, colon, stomach, pancreas and lung. Presumptive amplification oncogenes were identified by barcode enrichment as a proxy for increased proliferation. Iterative analysis validated DYRK2 at 12q15, encoding a serine-threonine kinase, as an amplified head and neck squamous carcinoma oncogene in p53 -/- oral mucosal organoids. Similarly, FGF3 , amplified at 11q13 in 41% of esophageal squamous carcinomas, was validated in p53 -/- esophageal organoids in vitro and in vivo with pharmacologic inhibition by small molecule and soluble receptor FGFR antagonists. Our studies establish the feasibility of pan-organoid contextual modeling of pan-cancer candidat...
8. Publisher Correction: Clonal replacement and heterogeneity in ...
May 30, 2019 · Katherine McNamara, Ruping Sun, Zheng Hu, Zhicheng Ma, Jie Ding & Christina Curtis. Stanford Cancer Institute, Stanford University School of ...
The original version of this Article omitted from the Author Contributions statement that ‘R.S. and J.G.R contributed equally to this work.’ This has been corrected in both the PDF and HTML versions of the Article.
